Senecavirus A - SVA (Seneca Valley Virus)
Senecavirus A - SVA (Seneca Valley Virus) belongs to Genus Senecavirus within the Picornaviridae family. The clinical signs are characterized by vesicles and coalescing erosions on the snouts and coronary bands in infected sows, nursery, and finishing pigs (Figure 1). Acute mortality in neonatal piglets has also been sporadically reported.
Previous attempts to fulfill Koch postulates with SVA have been unsuccessful, and data is lacking on modes of transmission, incubation period, and duration of viral shedding. Viremia associated with SVA is unknown, but the lab has retrieved whole genome sequences of SVA from sow serum. The majority of SVA sequences available from GenBank consist of VP1 gene (Figure 2).
The Minnesota Veterinary Diagnostic Laboratory (MNVDL) has identified SVA by real time PCR from snouts, hooves, lymph nodes, and serum from affected sows that tested negative for FMDV, VSV, SVDV, and VESV. In addition, the virus has been detected in several tissues including brain, liver, spleen, lung, intestine, and heart from acutely dead piglets born from clinically infected sows.
View the powerpoint slides from a presentation by Dr. Matt Sturos March 28, 2017.
- UMN VDL experience with Seneca Valley Virus
- VDL Develops Antibody Test for SVV (article)
- Journal Article on Seneca Valley Virus
Vannucci et al, Identification and Complete Genome of Seneca Valley Virus in Vesicular Fluid and Sera of Pigs Affected with Idiopathic Vesicular Disease, Brazil
- Information from AASV on Seneca Valley Virus
- USDA Recommendations for Swine with Potential Vesicular Disease\
- Longitudinal Study of Senecavirus A